Isabelle Goulet


 

Contact information

Scientive, PO Box 201, North Gower, Ontario, Canada K0A 2T0
Email: isabelle@scientive.ca
Tel.: 613-276-3423

 

Expertise/Questions/Interest areas

Expertise: Genetics, epigenetics, molecular biology, cellular biology, cancer biology

Question/Interest Area: understanding how mental events can be transduced into specific bodily changes (e.g. direct and distant mind-body interactions (bio-psychokinesis), intentionality).

 

Access to equipment or laboratory resources

Access to a fully equipped laboratory for cellular and molecular studies (in vitro and in vivo)

 

Education field/universities attended

B.Sc. Microbiology (Universite Laval, Quebec City, Quebec, Canada)

M.Sc. Cellular and Molecular Biology (Universite Laval)

Ph.D. Cellular and Molecular Medicine (University of Ottawa, Ontario, Canada)

 

Highest Education Level (high school; bachelor's degree; post-bachelor's degree like Master's, Professional or Doctorate degree)

Doctorate degree

 

Past and current affiliations

Scientive

 

Publications

 

1.    Baldwin RM, Morettin A, Paris G, Goulet I, Côté J. (2012) Alternatively spliced protein arginine methyltransferase 1 isoform PRMT1v2 promotes the survival and invasiveness of breast cancer cells. Cell Cycle. 11(24):4597-612.

 

2.     Chen, Y.-C., Milliman, E.J., Goulet, I., Côté, J., Jackson, C.A., Vollbracht, J.A., and Yu, M.C. (2010) Protein arginine methylation facilitates co-transcriptional recruitment of pre-mRNA splicing factors. Molecular and Cellular Biology. 30:5245-56.

 

3.     Dincbas-Renqvist, V., Pépin, G., Rakonjac, M., Plante, I., Ouellet, D.L., Hermansson, A., Goulet, I., Doucet, J., Samuelsson, B., Râdmark, O., and Provost, P. (2009) Human Dicer C-terminus functions as a 5-lipoxygenase binding domain. Biochimica et Biophysica Acta – Gene Regulatory Mechanisms. 1789:99-108.

 

4.     Zhao, T.T., Graber, T.E., Jordan, L.E., Cloutier, M., Lewis, S.M., Goulet, I., Côté, J., and Holcik, M. (2009) HnRNP A1 regulates UV-induced NF-kB signalling through destabilization of cIAP1 mRNA. Cell Death and Differentiation. 16:244-52.

 

5.     Goulet, I., Boisvenue, S., Mokas, S., Mazroui, R. and Côté, J. (2008) TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.Human Molecular Genetics. 17: 3055-74.

 

6.     Goulet, I., Gauvin, G., Boisvenue, S., and Côté, J. (2007) Alternative splicing yields protein arginine methyltransferase 1 isoforms with distinct activity, substrate specificity and subcellular localization. Journal of Biological Chemistry282:33009-21.

 

7.     Goulet, I./Brodeur, I./Tremblay, C.S., Charbonneau, C., Delisle, M.C., Godin, C., Huard, C., Khandjian, E.W., Buchwald, M., Levesque, G., and Carreau, M. (2004) Regulation of the Fanconi anemia group C protein through proteolytic modification. Journal of Biological Chemistry. 279:4713-4720.

 

8.     Aube, M., Lafrance, M., Charbonneau, C., Goulet, I., and Carreau, M. (2002) Hematopoietic stem cells from fancc(-/-) mice have lower growth and differentiation potential in response to growth factors. Stem Cells. 20:438-447.